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It also negatively impacts reproductive, metabolic, and psychological health (8)

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Substrates of AKT include enzymes that are involved in the regulation glucose and glycogen homeostasis as well as transcription factors that are responsible for the expression of several genes encoding glucose and glycogen metabolic enzymes

Children aged 412 years were diagnosed with ASD according to DSM criteria, both boys and girls were included, and the study explicitly excluded participants with major psychiatric comorbidities such as ADHD, depressions, bipolar disorder, anxiety disorders, epilepsy, severe intellectual disabilities, or recent antipsychotic use, ensuring relative homogeneous sample focused on irritability