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Among patients with type 2 diabetes, discontinuation remained high at 46.5% within the first year

Stress management: Research shows chronic glucocorticoid exposure (such as stress hormones produced by the adrenals) may alter GLP-1 signaling, and broader human evidence links glucocorticoid excess to impaired satiety signaling overall

In some people, the gut may respond with more sensitivity or changes in intestinal fluid balance, which can lead to looser stools or diarrhea, she explains

As these drugs become more popular for weight management and diabetes treatment, many users report distressing side effects

Over time, the body adapts to appetite suppression, making results harder to sustain

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