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Exendin-4, a stable synthetic form of GLP-1, is commonly used clinically for diabetes treatment because GLP-1 has a short half-life (Kastin and Akerstrom, 2003) and has a neuroprotective role in some neurological disorders (Mora and Johnson, 2017), oral administration of liraglutide (3 mg) (Manigault and Thurston, 2016), and subcutaneous treatment of liraglutide for 20 weeks (1.2 to 3 mg) (Onoviran et al., 2019)

NICE guidance emphasises structured lifestyle programmes that include: Dietary modifications : Focus on whole foods, increased fibre intake, reduced processed foods, and appropriate portion control

Gastric emptying and levothyroxine absorption : GLP-1 receptor agonists significantly slow gastric emptying, which is part of their therapeutic mechanism

semaglutide is taken weekly, produces greater results, but is pricier and more likely to cause GI side effects