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In rats, GLP-1 (7-36amide) and, perhaps paradoxically, the GLP-1R antagonist exendin (939), dose-dependently cause relaxation of the aorta, potentially via elevation of cAMP formation and activation of K ATP channels [624]

Semaglutide 1.0 mg significantly reduced body weight versus dulaglutide 3.0 and 4.5 mg with an ETD of 2.65 kg (95% CI 3.57, 1.73) and 1.95 kg (95% CI 2.87, 1.03), respectively

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But its not necessary to be diabetic to take semaglutide

Why is research on GLP-1 therapy and neuropathy limited

When claims are drawn from these sources, they are attributed to "Omzo's published materials" or "per Omzo's Terms." FDA.gov primary sources: The FDA's public page on unapproved GLP-1 drugs, the April 30, 2026 FDA press release on the 503B Bulks List proposal, and the Federal Register notice 91 Fed