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doi: 10.1007/s10552-009-9399-7

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291 In addition, CRISPR-Cas9 screening also provided a genome-wide gene investigation related to the retrotransposition control of LINE1, revealing that the vertebrate-specific chromatin-modifying complex human silencing hub and the subunit of MORC family CW zinc finger protein 2 promoted the deposition of H3K9me3 to silence the transcription of LINE1 element

Also, the different mechanisms involved in the beneficial effects of MEM in the preclinical levels will be discussed

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