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This platform was developed utilizing unbiased weighted gene co-expression network analysis (WGCNA) from PHH microarray data obtained from an open data repository, TG-GATES

Lf, a transferrin (Tf) family member, consists of a single iron-binding glycoprotein chain with 690 amino acids

The LKKTETQ motif within the sequence is the primary active region responsible for actin binding and angiogenic activity in published research models

This observed cytotoxicity may be attributed to the elevated uptake of GSH and/or -EC, potentially disturbing GSH homeostasis

It triggers the AMP-activated protein kinase (AMPK) signaling cascade, which improves insulin sensitivity, increases glucose uptake, and encourages fatty acid oxidation, a crucial therapeutic target in insulin-resistant PCOS models
