glp-1 gip therapy alternatives 2025 What is the pipeline for future medications for obesity? GLP-1 Agonists Weight Loss Drugs

The beneficial clinical effects of GIP receptor antagonism are supported by comparable phenotypic traits of individuals with loss-of-function genetic receptor variants

Conflict of interest statement Within the last 36 months, FK has served on scientific advisory panels and/or been part of speaker's bureaus for, served as a consultant to and/or received research support from Amgen, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Gubra, MedImmune, MSD/Merck, Mundipharma, Norgine, Novo Nordisk, Sanofi and Zealand Pharma

Agents in this class are approved for treatment of type 2 diabetes and reduction of cardiovascular disease, as well as weight management

Get Moving: Exercise Increases GLP-1 When you exercise, especially through muscle contraction (like when you lift weights or do cardio), your body produces more GLP-1

It plays a central role in regulating postprandial glucose homeostasis by enhancing glucose-dependent insulin secretion, suppressing glucagon release, slowing gastric emptying, and modulating food intake and gut motility

J Endocrinol